Clinical Biochemistry in Drug Safety Evaluation
نویسندگان
چکیده
منابع مشابه
Drug Safety Evaluation
Despite the considerable number of newer antibacterials made available over the past decades, amoxicillin, alone or in combination with clavulanic acid, still accounts among the most widely used antibacterial agents. Although they are often considered ‘twin drugs’, they are different both in terms of antibacterial activities and of safety profile. It is well documented that the clavulanate comp...
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Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be translated into the development of predictive in silico models for use in the drug discovery phase. We identified 13 hepatotoxic side effects...
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The current standard method for adverse symptom monitoring in clinical trials is staff reporting [1, 2]. This is generally conducted via a complex process of data transfer, during which clinicians interview patients and then document impressions in medical charts ad hoc; study personnel abstract these charts and convert reported symptoms to a standard lexicon such as the Common Terminology Crit...
متن کاملClinical Laboratory Safety Data in Drug Studies
Clinical laboratory measurements are an integral component of most drug studies for two major reasons, firstly to act as an efficacy endpoint in monitoring the success or otherwise of therapy and secondly to ensure patient safety on any new drug or reformulation. The pharmaceutical industry rarely employs physicians and scientists with expertise in clinical laboratory medicine. As such, there i...
متن کاملInfective endocarditis in intravenous drug users, evaluation of clinical and para-clinical presentation
Introduction: 60 percent of hospitalization causes of intravenous drug users are infection, of which 5 to 15 percent of them due to endocorditis. Infective endocorditis is a common infection among intravenous drug users and can cause high mortality and morbidity. This study was conducted to evaluate clinical and para-clinical presentations of drug users. Methods: In a descriptive study we...
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ژورنال
عنوان ژورنال: Proceedings of the Association of Clinical Biochemists
سال: 1968
ISSN: 0369-8564
DOI: 10.1177/036985646800500603